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Kemper is best known for playing the roles of Erin Hannon in the sitcom The Office (2009–2013) and Kimmy Schmidt in the sitcom Unbreakable Kimmy Schmidt (2015–2019), the latter of which earned her two consecutive nominations for the Primetime Emmy Award for Outstanding Lead Actress in a Comedy Series. She has also appeared in films, notably Bridesmaids (2011), 21 Jump Street (2012), and Sex Tape (2014). In 2018, she released her debut book, My Squirrel Days.

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